The previous chapter describes universal and widely available interventions designed to strengthen parenting and support parents of young children. This chapter turns to evidence-based and evidence-informed interventions used in a variety of settings (e.g., health care, education, the home) with some evidence of effectiveness in supporting parents and parenting knowledge, attitudes, and practices among (1) parents of children with special needs; (2) parents facing special personal and situational adversities; and (3) parents who have in some way been involved with the child welfare system, including those who have a history of or are believed to be at risk for maltreatment and foster parents. These interventions target specific populations of interest named in the committee’s statement of task (Box 1-2 in Chapter 1), such as parents of children with disabilities, parents with mental health conditions, and parents with a history of substance abuse, as well as other populations of parents the committee believes also warrant specific attention based on its review of the evidence.